ARG59610

anti-HEXIM2 antibody

anti-HEXIM2 antibody for Western blot and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes HEXIM2
Tested Reactivity Hu, Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name HEXIM2
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 147-286 of Human HEXIM2 (NP_653209.1).
Conjugation Un-conjugated
Alternate Names Protein HEXIM2; L3; Hexamethylene bis-acetamide-inducible protein 2

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:200 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse brain and HeLa
Observed Size 45 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 124790 Human HEXIM2

GeneID: 71059 Mouse HEXIM2

Swiss-port # Q3TVI4 Mouse Protein HEXIM2

Swiss-port # Q96MH2 Human Protein HEXIM2

Gene Symbol HEXIM2
Gene Full Name hexamethylene bis-acetamide inducible 2
Background This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Function Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. [UniProt]
Cellular Localization Nucleus. [UniProt]
Calculated MW 32 kDa