ARG43824
anti-HIF-1 alpha antibody
anti-HIF-1 alpha antibody for ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes HIF-1 alpha |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ELISA, ICC/IF, IHC-P, WB |
| Specificity | Human,Mouse,Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | HIF-1 alpha |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of human HIF-1alpha. |
| Conjugation | Un-conjugated |
| Protein Full Name | Hypoxia-inducible factor 1-alpha |
| Alternate Names | HIF1A; Hypoxia Inducible Factor 1 Subunit Alpha; BHLHe78; PASD8; MOP1; Class E Basic Helix-Loop-Helix Protein 78; PAS Domain-Containing Protein 8; Member Of PAS Protein 1; HIF-1alpha; HIF1; Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor); Basic-Helix-Loop-Helix-PAS Protein MOP1; Hypoxia-Inducible Factor 1-Alpha; HIF-1-Alpha; Hypoxia Inducible Factor 1 Alpha Subunit; Hypoxia-Inducible Factor1alpha; Member Of PAS Superfamily 1; ARNT Interacting Protein; ARNT-Interacting Protein; HIF1-ALPHA; HIF1-Alpha; BHLHE78; HIF-1A |
Application Instructions
| Application Suggestion |
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| Observed Size | 92-130 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | Tris-Glycine, 50% Glycerol, 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HIF1A |
| Gene Full Name | Hypoxia Inducible Factor 1 Subunit Alpha |
| Background | This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] |
| Function | Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. [UniProt] |
| Cellular Localization | Cytoplasm, Nucleus. [UniProt] |
| Calculated MW | 93 kDa |
| PTM | Acetylation, Glycoprotein, Hydroxylation, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation. [UniProt] |
