ARG43805
anti-HMGN3 antibody
anti-HMGN3 antibody for Western blot and Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes HMGN3 |
|---|---|
| Tested Reactivity | Ms |
| Predict Reactivity | Hu, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | HMGN3 |
| Antigen Species | Human |
| Immunogen | Recombinant full length protein corresponding to HMGN3 |
| Conjugation | Un-conjugated |
| Alternate Names | HMGN3; High Mobility Group Nucleosomal Binding Domain 3; TRIP7; High Mobility Group Nucleosome-Binding Domain-Containing Protein 3; TR-Interacting Protein 7; Thyroid Hormone Receptor Interacting Protein 7; Thyroid Receptor-Interacting Protein 7; Thyroid Hormone Receptor Interactor 7; PNAS-24; PNAS-25; TRIP-7 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse adrenal gland | ||||
| Observed Size | 11 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen |
| Buffer | pH 7.4 PBS, 0.05% NaN3, and 40% Glycerol |
| Concentration | 0.7 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9DCB1 Mouse High mobility group nucleosome-binding domain-containing protein 3 |
|---|---|
| Gene Symbol | HMGN3 |
| Gene Full Name | High Mobility Group Nucleosomal Binding Domain 3 |
| Background | The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016] |
| Function | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). ( HMGN3_HUMAN,Q15651 ) |
| Cellular Localization | Nucleus |
| Calculated MW | 11 kDa |
| PTM | Phosphoprotein |
Images (1) Click the Picture to Zoom In
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ARG43805 anti-HMGN3 antibody WB image
Western blot: 40 µg of mouse adrenal gland tissu stained with ARG43805 anti-HMGN3 antibody at dilution 1: 500.
