ARG56213
anti-HNMT antibody
anti-HNMT antibody for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes HNMT |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 432CT31.4.2 |
| Isotype | IgG1 |
| Target Name | HNMT |
| Antigen Species | Human |
| Immunogen | Purified His-tagged HNMT protein fragment. |
| Conjugation | Un-conjugated |
| Alternate Names | HMT; Histamine N-methyltransferase; EC 2.1.1.8; HNMT-S1; HNMT-S2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HepG2 |
Properties
| Form | Liquid |
|---|---|
| Purification | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide. |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HNMT |
| Gene Full Name | histamine N-methyltransferase |
| Background | In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. [UniProt] |
| Cellular Localization | Cytoplasm. |
| Calculated MW | 33 kDa |
