ARG10164
anti-HPV16 E7 antibody [716-281]
anti-HPV16 E7 antibody [716-281] for ELISA,Western blot and Virus
Microbiology and Infectious Disease antibody
Overview
| Product Description | Mouse Monoclonal antibody [716-281] recognizes HPV16 E7 |
|---|---|
| Tested Reactivity | Virus |
| Tested Application | ELISA, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 716-281 |
| Isotype | IgG2b |
| Target Name | HPV16 E7 |
| Immunogen | HPV oncoprotein E7, types 16 & 18 |
| Conjugation | Un-conjugated |
Application Instructions
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G affinity purified |
| Buffer | PBS (pH 7.2) and 0.1% Sodium azide |
| Preservative | 0.1% Sodium azide |
| Concentration | 1.0-2.0 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | E7 |
|---|---|
| Gene Full Name | transforming protein |
| Function | E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity). [UniProt] |
| Research Area | Microbiology and Infectious Disease antibody |
| Calculated MW | 11 kDa |
