ARG56108
anti-HPV16 L1 antibody [CamVir-1]
anti-HPV16 L1 antibody [CamVir-1] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and HPV
Overview
| Product Description | Mouse Monoclonal antibody [CamVir-1] recognizes HPV16 L1 |
|---|---|
| Tested Reactivity | HPV |
| Tested Application | ICC/IF, IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | CamVir-1 |
| Isotype | IgG2a, kappa |
| Target Name | HPV16 L1 |
| Antigen Species | Virus |
| Immunogen | Human papilloma virus type 16, major capsid protein L1. |
| Conjugation | Un-conjugated |
| Alternate Names | Major capsid protein L1 |
Application Instructions
| Cross Reactivity Note | Virus (HPV-16) | ||||||
|---|---|---|---|---|---|---|---|
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Citrate buffer (pH 6.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 0.1 mg/ml BSA |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | L1 |
|---|---|
| Gene Full Name | major capsid L1 protein |
| Function | Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2. [UniProt] |
| Cellular Localization | Nuclear |
