ARG66738

anti-HSD17B11 antibody

anti-HSD17B11 antibody for Western blot and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes HSD17B11
Tested Reactivity Hu, Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name HSD17B11
Antigen Species Human
Immunogen Synthetic peptide between aa. 71-120 of Human HSD17B11.
Conjugation Un-conjugated
Alternate Names Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; 17-beta-hydroxysteroid dehydrogenase 11; retSDR2; 17-beta-HSD XI; Short chain dehydrogenase/reductase family 16C member 2; 17-beta-HSD 11; SDR16C2; 17betaHSD11; Dehydrogenase/reductase SDR family member 8; PAN1B; 17-beta-hydroxysteroid dehydrogenase XI; 17BHSD11; RETSDR2; Estradiol 17-beta-dehydrogenase 11; 17bHSD11; 17-BETA-HSD11; DHRS8; 17-BETA-HSDXI; Retinal short-chain dehydrogenase/reductase 2; EC 1.1.1.62; 17betaHSDXI

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control 293 and Raw264.7
Observed Size 32 ~ 34 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol and 0.5% BSA
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 114664 Mouse HSD17B11

GeneID: 51170 Human HSD17B11

Swiss-port # Q8NBQ5 Human Estradiol 17-beta-dehydrogenase 11

Swiss-port # Q9EQ06 Mouse Estradiol 17-beta-dehydrogenase 11

Gene Symbol HSD17B11
Gene Full Name hydroxysteroid (17-beta) dehydrogenase 11
Background Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
Function Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. [UniProt]
Cellular Localization Secreted. [UniProt]
Calculated MW 33 kDa