ARG54468
anti-Heme Oxygenase 1 antibody [GTS-1]
anti-Heme Oxygenase 1 antibody [GTS-1] for ELISA,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody [GTS-1] recognizes Heme Oxygenase 1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Species Does Not React With | Rb |
| Tested Application | ELISA, IHC-P, WB |
| Specificity | This antibody reacts with human, ratand mouse heme oxygenase 1. It does not react with rabbit heme oxygenase I or heme oxygenase 2. This antibody will inhibit the activity of human or rat heme oxygenase 1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | GTS-1 |
| Isotype | IgG1 |
| Target Name | Heme Oxygenase 1 |
| Antigen Species | Rat |
| Immunogen | Rat heme oxygenase 1. |
| Conjugation | Un-conjugated |
| Alternate Names | bK286B10; Heme oxygenase 1; HO-1; EC 1.14.99.3; HMOX1D; HSP32 |
Application Instructions
| Application Note | ELISA: 1:10,000 dilution with solid phase antigen. Western blot: 5 - 10 ug/ml. Immunohistochemistry: 5 - 10 ug/ml (for use on human frozen or paraffin embedded tissue). Heme oxygenase 1 activity assays. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
Properties
| Form | Liquid |
|---|---|
| Buffer | 10 mM PBS (pH 7.4) and 1% BSA |
| Stabilizer | 1% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Hmox1 |
| Gene Full Name | heme oxygenase 1 |
| Background | Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008] |
| Function | Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. [UniProt] |
| Highlight | Related products: Heme Oxygenase 1 antibodies; Heme Oxygenase 1 ELISA Kits; Heme Oxygenase 1 Duos / Panels; Anti-Mouse IgG secondary antibodies; Related news: Keap1-Nrf2-ARE antibody panel is launched |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| Calculated MW | 33 kDa |
Clone References
Exendin-4 ameliorates renal ischemia-reperfusion injury in the rat.
WB /
In vivo nanoneurotoxicity screening using oxidative stress and neuroinflammation paradigms.
Adaphostin toxicity in a sensitive non-small cell lung cancer model is mediated through Nrf2 signaling and heme oxygenase 1.
WB / Human
Heme oxygenase 1 protects against hepatic hypoxia and injury from hemorrhage via regulation of cellular respiration.
WB / Mouse, Rat
Molecular insights into beta-galactoside alpha2,6-sialyltransferase secretion in vivo.
WB / Rat
