ARG45028
anti-Histone H2B acetyl (Lys11) antibody [RM456]
anti-Histone H2B acetyl (Lys11) antibody [RM456] for ELISA,Western blot and Human
Overview
| Product Description | Rabbit monoclonal antibody recognizes Histone H2B acetyl (Lys11). |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, WB |
| Specificity | This antibody reacts to Histone H2B acetylated at Lysine 11 (K11ac). No cross reactivity with other acetylated Lysines in histones. |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | RM456 |
| Isotype | IgG |
| Target Name | Histone H2B |
| Antigen Species | Human |
| Immunogen | An acetyl-peptide corresponding to Acetyl-Histone H2B (Lys11). |
| Conjugation | Un-conjugated |
| Alternate Names | H2BC4; H2B Clustered Histone 4; H2B/L; HIST1H2BC; H2B.1; H2BFL; Histone Cluster 1 H2B Family Member C; H2B Histone Family, Member L; Histone H2B Type 1-C/E/F/G/I; Histone Cluster 1, H2bc; Histone 1, H2bc; Histone H2B.1 A; Histone H2B.L; Histone H2B.A; Histone H2B.G; Histone H2B.H; Histone H2B.K; DJ221C16.3; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI; H2BC10; H2BC6; H2BC7; H2BC8; H2BFH; H2BFG; H2BFA; H2BFK; H2B/A; H2B/G; H2B/H; H2B/K |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Stabilizer | 50% Glycerol, 1% BSA and 0.09% |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | H2BC4 |
|---|---|
| Gene Full Name | H2B Clustered Histone 4 |
| Background | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. The main transcript variant of this gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. This transcript variant lacks a polyA tail but instead contains a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Apr 2020] |
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. [Uniprot] |
| Cellular Localization | Chromosome, Nucleosome core, Nucleus. [Uniprot] |
