ARG22413
anti-Histone H4 (Acetylated) antibody
anti-Histone H4 (Acetylated) antibody for ChIP,ELISA,ICC/IF,Immunoprecipitation,Western blot and Arabidopsis,D. melanogaster ,Human,Mouse,Yeast,Zebrafish
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Histone H4 (Acetylated) |
|---|---|
| Tested Reactivity | Hu, Ms, Arabi, Dm, Yeast, Zfsh |
| Predict Reactivity | Amph, Mamm, Plnt |
| Tested Application | ChIP, ELISA, ICC/IF, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Histone H4 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated peptide acetylated at lysines 5,8,12,16: SGRGAcKGGAcKGLGAcKGGAAcKRHYC. |
| Conjugation | Un-conjugated |
| Alternate Names | H4/o |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | Serum and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HIST2H4B |
| Gene Full Name | histone cluster 2 H4 family member b |
| Background | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015] |
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Calculated MW | 11 kDa |
