ARG54183
anti-Hsp 90 alpha antibody
anti-Hsp 90 alpha antibody for Western blot and Human,Mouse,Rat,Monkey
Cancer antibody; Signaling Transduction antibody
Overview
Product Description | Mouse Monoclonal antibody recognizes Hsp 90 alpha |
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Tested Reactivity | Hu, Ms, Rat, Mk |
Tested Application | WB |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Target Name | Hsp 90 alpha |
Antigen Species | Human |
Immunogen | Purified recombinant human Hsp90 alpha protein fragments expressed in E.coli |
Conjugation | Un-conjugated |
Alternate Names | EL52; Hsp90; HSPC1; Heat shock 86 kDa; LAP-2; HSP90N; LAP2; HSP90A; HSPCAL4; HSP89A; HSP86; HSP 86; HSPCA; Lipopolysaccharide-associated protein 2; HSPCAL1; LPS-associated protein 2; HSPN; Renal carcinoma antigen NY-REN-38; Heat shock protein HSP 90-alpha; Hsp89 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
Observed Size | 90 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified |
Buffer | PBS (pH 7.4), 0.02% Sodium azide, 1mg/ml BSA and 50% Glycerol |
Preservative | 0.02% Sodium azide |
Stabilizer | 1mg/ml BSA, 50% Glycerol |
Concentration | 0.6 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | HSP90AA1 |
Gene Full Name | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
Background | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. |
Function | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. [UniProt] |
Cellular Localization | Cytoplasm. Melanosome. Cell membrane. |
Research Area | Cancer antibody; Signaling Transduction antibody |
Calculated MW | 85 kDa |
PTM | ISGylated. S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1. |