ARG59716

anti-ID1 antibody

anti-ID1 antibody for ICC/IF and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes ID1
Tested Reactivity Hu, Ms, Rat
Tested Application ICC/IF
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name ID1
Antigen Species Human
Immunogen Synthetic peptide derived from Human ID1.
Conjugation Un-conjugated
Alternate Names DNA-binding protein inhibitor ID-1; Class B basic helix-loop-helix protein 24; Inhibitor of DNA binding 1; ID; bHLHb24; Inhibitor of differentiation 1

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:50 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 25261 Rat ID1

GeneID: 3397 Human ID1

Swiss-port # P41134 Human DNA-binding protein inhibitor ID-1

Swiss-port # P41135 Rat DNA-binding protein inhibitor ID-1

Gene Symbol ID1
Gene Full Name inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Background The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). [UniProt]
Cellular Localization Cytoplasm. Nucleus. [UniProt]
Calculated MW 16 kDa