ARG55426

anti-IGF2BP2 antibody

anti-IGF2BP2 antibody for Flow cytometry,Western blot and Human

Gene Regulation antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody

Overview

Product Description

Rabbit Polyclonal antibody recognizes IGF2BP2

Tested Reactivity Hu
Predict Reactivity Ms
Tested Application FACS, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name IGF2BP2
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 530-556 (C-terminus) of Human IGF2BP2.
Conjugation Un-conjugated
Alternate Names IMP2; VICKZ2; Hepatocellular carcinoma autoantigen p62; IMP-2; VICKZ family member 2; IGF2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2; Insulin-like growth factor 2 mRNA-binding protein 2

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:10 - 1:50
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HepG2

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 10644 Human IGF2BP2

Swiss-port # Q9Y6M1 Human Insulin-like growth factor 2 mRNA-binding protein 2

Gene Symbol IGF2BP2
Gene Full Name insulin-like growth factor 2 mRNA binding protein 2
Background This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]
Function RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. [UniProt]
Cellular Localization Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules
Research Area Gene Regulation antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody
Calculated MW 66 kDa