ARG40987

anti-IGFBP3 antibody

anti-IGFBP3 antibody for Western blot and Human,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes IGFBP3
Tested Reactivity Hu, Rat
Predict Reactivity Hm
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name IGFBP3
Antigen Species Human
Immunogen Synthetic peptide corresponding to aa. 182-198 of Human IGFBP3 (IKKGHAKDSQRYKVDYE).
Conjugation Un-conjugated
Alternate Names IBP-3; IBP3; Insulin-like growth factor-binding protein 3; IGFBP-3; IGF-binding protein 3; BP-53

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer 0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA.
Preservative 0.05% Thimerosal and 0.05% Sodium azide
Stabilizer 5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 24484 Rat IGFBP3

GeneID: 3486 Human IGFBP3

Swiss-port # P15473 Rat Insulin-like growth factor-binding protein 3

Swiss-port # P17936 Human Insulin-like growth factor-binding protein 3

Gene Symbol IGFBP3
Gene Full Name insulin-like growth factor binding protein 3
Background This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. [UniProt]
Cellular Localization Secreted. [UniProt]
Calculated MW 32 kDa
PTM Phosphorylated by FAM20C in the extracellular medium. [UniProt]