ARG59570
anti-IL1 Receptor 1 antibody
anti-IL1 Receptor 1 antibody for Western blot and Human
Overview
Product Description | Rabbit Polyclonal antibody recognizes IL1 Receptor 1 |
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Tested Reactivity | Hu |
Tested Application | WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | IL1 Receptor 1 |
Antigen Species | Human |
Immunogen | Recombinant protein of Human IL1 Receptor 1. |
Conjugation | Un-conjugated |
Alternate Names | Interleukin-1 receptor alpha; sIL-1R1; p80; CD121A; mIL-1RI; IL1R; P80; Interleukin-1 receptor type I; IL1RA; D2S1473; Interleukin-1 receptor type 1; IL-1R-alpha; IL-1RT-1; CD121 antigen-like family member A; IL-1R-1; sIL-1RI; IL-1RT1; mIL-1R1; CD antigen CD121a |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
Positive Control | BT-474 | ||||
Observed Size | 80 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | IL1R1 |
Gene Full Name | interleukin 1 receptor, type I |
Background | This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013] |
Function | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. [UniProt] |
Cellular Localization | Membrane; Single-pass type I membrane protein. Cell membrane. Secreted. [UniProt] |
Calculated MW | 65 kDa |
PTM | A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. [UniProt] |