ARG23953
anti-IL12 / IL23 p40 antibody [SQab19137] (low endotoxin)
anti-IL12 / IL23 p40 antibody [SQab19137] (low endotoxin) for Neutralizing and Mouse
Overview
| Product Description | Low endotoxin Rat Monoclonal antibody [SQab19137] recognizes IL12 / IL23 p40 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | Neut |
| Specificity | Native and recombinant p40 subunit of Mouse IL12 and IL23. The antibody recognizes p40 monomer, p40 homodimer and IL12 p70 heterodimer (p40 + p35) and IL23 heterodimer (p40 + p19). |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | SQab19137 |
| Isotype | IgG2a |
| Target Name | IL12 / IL23 p40 |
| Antigen Species | Mouse |
| Immunogen | Recombinant Mouse IL12 p70 protein. |
| Conjugation | Un-conjugated |
| Alternate Names | CLMF; Interleukin-12 subunit beta; NK cell stimulatory factor chain 2; NKSF; CLMF p40; NKSF2; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF2; IL-12 subunit p40; IMD29; IMD28; IL-12B |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Purification Note | 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg. |
| Buffer | PBS |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IL12B |
| Gene Full Name | interleukin 12B |
| Background | This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008] |
| Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 37 kDa |
| PTM | Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified. [UniProt] |
