ARG55331
anti-IL12RB1 antibody
anti-IL12RB1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Immune System antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IL12RB1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IL12RB1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human IL12RB1 |
| Conjugation | Un-conjugated |
| Alternate Names | Interleukin-12 receptor subunit beta-1; IL-12R-beta-1; IL12RB; IL-12R-BETA1; IL-12 receptor beta component; IL-12RB1; IL-12 receptor subunit beta-1; IMD30; CD212; IL-12R subunit beta-1; CD antigen CD212 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | Mouse liver |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P42701 Human Interleukin-12 receptor subunit beta-1 Swiss-port # Q60837 Mouse Interleukin-12 receptor subunit beta-1 |
|---|---|
| Gene Symbol | IL12RB1 |
| Gene Full Name | interleukin 12 receptor, beta 1 |
| Background | The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| Function | Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. [UniProt] |
| Research Area | Immune System antibody |
| Calculated MW | 73 kDa |
