ARG23956
anti-IL13 antibody [SQab19140] (low endotoxin)
anti-IL13 antibody [SQab19140] (low endotoxin) for Neutralizing and Human,Rhesus Monkey,Macaque,Marmoset
Overview
| Product Description | Low endotoxin Rat Monoclonal antibody [SQab19140] recognizes IL13 |
|---|---|
| Tested Reactivity | Hu, Macaq, Marmoset, R. Mk |
| Tested Application | Neut |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | SQab19140 |
| Isotype | IgG1 |
| Target Name | IL13 |
| Antigen Species | Human |
| Immunogen | Recombinant Human IL13 protein. |
| Conjugation | Un-conjugated |
| Alternate Names | Interleukin-13; P600; IL-13 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Purification Note | 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg. |
| Buffer | PBS |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IL13 |
| Gene Full Name | interleukin 13 |
| Background | This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] |
| Function | Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 16 kDa |
