ARG23959
anti-IL17 / IL17A antibody [SQab19143] (low endotoxin)
anti-IL17 / IL17A antibody [SQab19143] (low endotoxin) for Neutralizing and Human,Rhesus Monkey,Macaque,Marmoset
Overview
| Product Description | Low endotoxin Mouse Monoclonal antibody [SQab19143] recognizes IL17 / IL17A |
|---|---|
| Tested Reactivity | Hu, Macaq, Marmoset, R. Mk |
| Tested Application | Neut |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SQab19143 |
| Isotype | IgG1 |
| Target Name | IL17 / IL17A |
| Antigen Species | Human |
| Immunogen | Recombinant Human IL17A protein. |
| Conjugation | Un-conjugated |
| Alternate Names | IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | Neutralization dose 50 (ND50): The antibody neutralized the effect of IL17A at a ND50 value of 0.01 - 0.03 µg/ml when 10 ng/ml of recombinant Human IL17A was present. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Purification Note | 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg. |
| Buffer | PBS |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IL17A |
| Gene Full Name | interleukin 17A |
| Background | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
| Function | Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Highlight | Related products: IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Anti-Mouse IgG secondary antibodies; Related news: HMGB1, a biomarker and therapeutic target in COVID-19 |
| Calculated MW | 18 kDa |
| PTM | Found both in glycosylated and nonglycosylated forms. [UniProt] |
