ARG23954
anti-IL23 antibody [SQab19138] (low endotoxin)
anti-IL23 antibody [SQab19138] (low endotoxin) for Neutralizing and Human,Macaque
Overview
| Product Description | Low endotoxin Mouse Monoclonal antibody [SQab19138] recognizes IL23 |
|---|---|
| Tested Reactivity | Hu, Macaq |
| Tested Application | Neut |
| Specificity | Native and recombinant Human IL23. The antibody recognizes the p19 subunit of the IL23 heterodimer (p40 + p19). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SQab19138 |
| Isotype | IgG2b |
| Target Name | IL23 |
| Antigen Species | Human |
| Immunogen | Recombinant Human IL23 protein. |
| Conjugation | Un-conjugated |
| Alternate Names | IL-23A; IL-23; IL-23 subunit alpha; IL23P19; IL-23p19; Interleukin-23 subunit alpha; IL-23-A; P19; SGRF; Interleukin-23 subunit p19 |
Application Instructions
| Application Suggestion |
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| Application Note | Neutralization dose 50 (ND50): The antibody neutralized the effect of IL23 at a ND50 value of 0.2 - 0.8 µg/ml when 10 ng/ml of recombinant Human IL23 was present. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Purification Note | 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg. |
| Buffer | PBS |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IL23A |
| Gene Full Name | interleukin 23, alpha subunit p19 |
| Background | This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008] |
| Function | Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. [UniProt] |
| Cellular Localization | Secreted. Note=Secreted upon association with IL12B. [UniProt] |
| Calculated MW | 21 kDa |
