ARG23960
anti-IL31 antibody [SQab19144] (low endotoxin)
anti-IL31 antibody [SQab19144] (low endotoxin) for Neutralizing and Human
Overview
| Product Description | Low endotoxin Mouse Monoclonal antibody [SQab19144] recognizes IL31 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | Neut |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SQab19144 |
| Isotype | IgG1 |
| Target Name | IL31 |
| Antigen Species | Human |
| Immunogen | Recombinant Human IL31 protein. |
| Conjugation | Un-conjugated |
| Alternate Names | IL-31; Interleukin-31 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | Neutralization dose 50 (ND50): The antibody neutralized the effect of Human IL31 at a ND50 value of 0.1 - 0.6 µg/ml when 50 ng/ml of recombinant Human IL31 was present. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Purification Note | 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg. |
| Buffer | PBS |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IL31 |
| Gene Full Name | interleukin 31 |
| Background | IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008] |
| Function | Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 18 kDa |
