ARG40346

anti-IMPDH1 antibody

anti-IMPDH1 antibody for Western blot and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes IMPDH1
Tested Reactivity Hu, Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name IMPDH1
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 434-563 of Human IMPDH1 (NP_899066.1).
Conjugation Un-conjugated
Alternate Names IMPD1; EC 1.1.1.205; IMP dehydrogenase 1; IMPDH-I; IMPDH 1; LCA11; IMPD 1; IMPD; sWSS2608; Inosine-5'-monophosphate dehydrogenase 1; RP10

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse lung and HL-60
Observed Size 57 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 23917 Mouse IMPDH1

GeneID: 3614 Human IMPDH1

Swiss-port # P20839 Human Inosine-5'-monophosphate dehydrogenase 1

Swiss-port # P50096 Mouse Inosine-5'-monophosphate dehydrogenase 1

Gene Symbol IMPDH1
Gene Full Name IMP (inosine 5'-monophosphate) dehydrogenase 1
Background The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. [UniProt]
Cellular Localization Cytoplasm. Nucleus. [UniProt]
Calculated MW 55 kDa