ARG40388

anti-IMPDH2 antibody

anti-IMPDH2 antibody for Western blot,ICC/IF and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes IMPDH2
Tested Reactivity Hu, Ms
Tested Application ICC/IF, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name IMPDH2
Antigen Species Human
Immunogen Recombinant full length protein of Human IMPDH2.
Conjugation Un-conjugated
Alternate Names IMPD2; EC 1.1.1.205; IMPDH-II; IMP dehydrogenase 2; IMPD 2; Inosine-5'-monophosphate dehydrogenase 2; IMPDH 2

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:50 - 1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size 56 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol.
Preservative 0.01% Sodium azide
Stabilizer 30% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 23918 Mouse IMPDH2

GeneID: 3615 Human IMPDH2

Swiss-port # P12268 Human Inosine-5'-monophosphate dehydrogenase 2

Swiss-port # P24547 Mouse Inosine-5'-monophosphate dehydrogenase 2

Gene Symbol IMPDH2
Gene Full Name IMP (inosine 5'-monophosphate) dehydrogenase 2
Background This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. [UniProt]
Cellular Localization Cytoplasm. Nucleus. [UniProt]
Calculated MW 56 kDa
PTM The N-terminus is blocked. [UniProt]