ARG66266
anti-IPO4 / Importin 4 antibody
anti-IPO4 / Importin 4 antibody for Western blot and Human
Overview
Product Description | Rabbit Polyclonal antibody recognizes IPO4 / Importin 4 |
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Tested Reactivity | Hu |
Tested Application | WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | IPO4 / Importin 4 |
Antigen Species | Human |
Immunogen | Fusion protein of Human IPO4 / Importin 4. |
Conjugation | Un-conjugated |
Alternate Names | Imp4b; Imp4; Importin-4b; Ran-binding protein 4; Importin-4; RanBP4 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Affinity purification with immunogen. |
Buffer | PBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol. |
Preservative | 0.05% Sodium azide |
Stabilizer | 40% Glycerol |
Concentration | 2.4 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | IPO4 |
Gene Full Name | importin 4 |
Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. [UniProt] |
Calculated MW | 119 kDa |