ARG66266

anti-IPO4 / Importin 4 antibody

anti-IPO4 / Importin 4 antibody for Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes IPO4 / Importin 4
Tested Reactivity Hu
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name IPO4 / Importin 4
Antigen Species Human
Immunogen Fusion protein of Human IPO4 / Importin 4.
Conjugation Un-conjugated
Alternate Names Imp4b; Imp4; Importin-4b; Ran-binding protein 4; Importin-4; RanBP4

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol.
Preservative 0.05% Sodium azide
Stabilizer 40% Glycerol
Concentration 2.4 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 79711 Human IPO4

Swiss-port # Q8TEX9 Human Importin-4

Gene Symbol IPO4
Gene Full Name importin 4
Function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. [UniProt]
Calculated MW 119 kDa