ARG66166
anti-IRX3 antibody
anti-IRX3 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IRX3 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IRX3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around aa. 240 - 320 (Center) of Human IRX3. |
| Conjugation | Un-conjugated |
| Alternate Names | IRX-1; Homeodomain protein IRXB1; Iroquois-class homeodomain protein IRX-3; IRXB1; Iroquois homeobox protein 3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P78415 Human Iroquois-class homeodomain protein IRX-3 Swiss-port # P81067 Mouse Iroquois-class homeodomain protein IRX-3 |
|---|---|
| Gene Symbol | IRX3 |
| Gene Full Name | iroquois homeobox 3 |
| Background | IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009] |
| Function | Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity). [UniProt] |
| Cellular Localization | Nucleus |
| Calculated MW | 52 kDa |
