ARG64782
anti-ITIH4 antibody
anti-ITIH4 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Cell Biology and Cellular Response antibody; Immune System antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes ITIH4 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Specificity | The immunizing peptide represents a region of the 35kDa chain. This chain is glycosylated giving rise to an apparent higher molecular weight. |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ITIH4 |
| Antigen Species | Human |
| Immunogen | ERLCVDPRHRQGPVN |
| Conjugation | Un-conjugated |
| Alternate Names | PK-120; PK120; Inter-alpha-inhibitor heavy chain 4; Gp120; H4P; GP120; Inter-alpha-trypsin inhibitor family heavy chain-related protein; Inter-alpha-trypsin inhibitor heavy chain H4; IHRP; ITIHL1; Plasma kallikrein sensitive glycoprotein 120; ITI heavy chain H4; ITI-HC4 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by antigen affinity chromatography. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q14624 Human Inter-alpha-trypsin inhibitor heavy chain H4 |
|---|---|
| Background | The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
| Research Area | Cell Biology and Cellular Response antibody; Immune System antibody |
| Calculated MW | 103 kDa |
| PTM | Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma. |
