ARG55235

anti-ITPA antibody

anti-ITPA antibody for Flow cytometry,ICC/IF,Immunohistochemistry,Western blot and Human,Mouse,Rat

Metabolism antibody; Signaling Transduction antibody

Overview

Product Description

Rabbit Polyclonal antibody recognizes ITPA

Tested Reactivity Hu, Ms, Rat
Predict Reactivity Bov, Chk, Xenopus
Tested Application FACS, ICC/IF, IHC, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name ITPA
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 24-51 (N-terminus) of Human ITPA.
Conjugation Un-conjugated
Alternate Names Inosine triphosphatase; My049; EC 3.6.1.19; Inosine triphosphate pyrophosphatase; Non-canonical purine NTP pyrophosphatase; NTPase; C20orf37; Putative oncogene protein hlc14-06-p; ITPase; HLC14-06-P; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; dJ794I6.3; Non-standard purine NTP pyrophosphatase

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:10 - 1:50
ICC/IF1:25
IHC1:50 - 1:100
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 16434 Mouse ITPA

GeneID: 311422 Rat ITPA

GeneID: 3704 Human ITPA

Gene Symbol ITPA
Gene Full Name inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Background This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Function Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. [UniProt]
Cellular Localization Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832}
Research Area Metabolism antibody; Signaling Transduction antibody
Calculated MW 21 kDa