ARG58823

anti-ITPR3 / IP3R3 antibody

anti-ITPR3 / IP3R3 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes ITPR3 / IP3R3
Tested Reactivity Hu, Ms, Rat
Predict Reactivity Chk
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name ITPR3 / IP3R3
Antigen Species Human
Immunogen Synthetic peptide corresponding to aa. 70-95 of Human ITPR3 (QYWKAKQTKQDKEKIADVVLLQKLQH).
Conjugation Un-conjugated
Alternate Names IP3R; Type 3 inositol 1,4,5-trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 3; Type 3 InsP3 receptor; InsP3R3; IP3R 3; IP3 receptor isoform 3; IP3R3

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P0.5 - 1 µg/ml
WB0.1 - 0.5 µg/ml
Application Note IHC-P: Antigen Retrieval: By heat mediation.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA.
Preservative 0.05% Sodium azide
Stabilizer 5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 16440 Mouse ITPR3

GeneID: 25679 Rat ITPR3

GeneID: 3710 Human ITPR3

Gene Symbol ITPR3
Gene Full Name inositol 1,4,5-trisphosphate receptor, type 3
Background This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
Function Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. [UniProt]
Cellular Localization Endoplasmic reticulum membrane; Multi-pass membrane protein. [UniProt]
Calculated MW 304 kDa
PTM Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity). [UniProt]