ARG58886
anti-ITPR3 / IP3R3 antibody
anti-ITPR3 / IP3R3 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ITPR3 / IP3R3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ITPR3 / IP3R3 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1630-1870 of Human ITPR3 / IP3R3 (NP_002215.2). |
| Conjugation | Un-conjugated |
| Alternate Names | IP3R; Type 3 inositol 1,4,5-trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 3; Type 3 InsP3 receptor; InsP3R3; IP3R 3; IP3 receptor isoform 3; IP3R3 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | LO2 | ||||
| Observed Size | 280 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q14573 Human Inositol 1,4,5-trisphosphate receptor type 3 |
|---|---|
| Gene Symbol | ITPR3 |
| Gene Full Name | inositol 1,4,5-trisphosphate receptor, type 3 |
| Background | This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010] |
| Function | Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. [UniProt] |
| Cellular Localization | Endoplasmic reticulum membrane, Multi-pass membrane protein. [UniProt] |
| Calculated MW | 304 kDa |
| PTM | Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity). [UniProt] |
