ARG23668
anti-Jagged 1 antibody [HMJ1-29]
anti-Jagged 1 antibody [HMJ1-29] for IHC-Frozen sections,Flow cytometry and Mouse,Rat
Overview
| Product Description | Hamster Monoclonal antibody [HMJ1-29] recognizes Jagged 1 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | FACS, IHC-Fr |
| Host | Hamster |
| Clonality | Monoclonal |
| Clone | HMJ1-29 |
| Isotype | IgG |
| Target Name | Jagged 1 |
| Antigen Species | Mouse |
| Immunogen | Jagged1-expressing CHO cells. |
| Conjugation | Un-conjugated |
| Alternate Names | Protein jagged-1; HJ1; AHD; Jagged1; AWS; CD antigen CD339; CD339; JAGL1; hJ1; AGS |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% Sodium azide. |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | JAG1 |
| Gene Full Name | jagged 1 |
| Background | The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] |
| Function | Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). [UniProt] |
| Calculated MW | 134 kDa |
