ARG56873
anti-Jagged 1 antibody [J1G53-3]
anti-Jagged 1 antibody [J1G53-3] for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [J1G53-3] recognizes Jagged 1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | J1G53-3 |
| Isotype | IgG1, kappa |
| Target Name | Jagged 1 |
| Antigen Species | Human |
| Immunogen | Recombinant Human Jagged1. |
| Conjugation | Un-conjugated |
| Alternate Names | Protein jagged-1; HJ1; AHD; Jagged1; AWS; CD antigen CD339; CD339; JAGL1; hJ1; AGS |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | WB: Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | 0.2 µm filtered. |
| Buffer | PBS (pH 7.4) |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | JAG1 |
| Gene Full Name | jagged 1 |
| Background | The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] |
| Function | Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Calculated MW | 134 kDa |
