ARG41426
anti-KAT7 / HBO1 / MYST2 antibody
anti-KAT7 / HBO1 / MYST2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KAT7 / HBO1 / MYST2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KAT7 / HBO1 / MYST2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human KAT7 / HBO1 / MYST2 Component of the HBO1 complex. |
| Conjugation | Un-conjugated |
| Alternate Names | EC 2.3.1.48; ZC2HC7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; HBOA; Lysine acetyltransferase 7; Histone acetyltransferase KAT7; MYST-2; HBO1; MYST2; Histone acetyltransferase binding to ORC1 |
Application Instructions
| Application Suggestion |
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | ~ 75 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 0.5 - 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KAT7 |
| Gene Full Name | K(lysine) acetyltransferase 7 |
| Function | Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. [UniProt] |
| Cellular Localization | Nucleus, nucleoplasm. Cytoplasm, cytosol. Nucleus. Note=Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067). [UniProt] |
| Calculated MW | 71 kDa |
| PTM | Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-85 and Thr-88 by CDK1 (PubMed:18250300). Autoacetylation at Lys-432 is required for proper function. [UniProt] |
