ARG23904
anti-KCNJ8 / kir6.1 antibody [S366-60]
anti-KCNJ8 / kir6.1 antibody [S366-60] for ICC/IF,Western blot and Human,Rat
Overview
| Product Description | Mouse Monoclonal antibody [S366-60] recognizes KCNJ8 / kir6.1 |
|---|---|
| Tested Reactivity | Hu, Rat |
| Predict Reactivity | Ms |
| Tested Application | ICC/IF, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S366-60 |
| Isotype | IgG2a |
| Target Name | KCNJ8 / kir6.1 |
| Antigen Species | Rat |
| Immunogen | Fusion protein corresponding to aa. 306-424 (Cytoplasmic C-terminus) of Rat KCNJ8 / kir6.1. |
| Conjugation | Un-conjugated |
| Alternate Names | ATP-sensitive inward rectifier potassium channel 8; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1; KIR6.1; Inward rectifier K |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | ~ 40 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.1% Sodium azide and 50% Glycerol. |
| Preservative | 0.1% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q15842 Human ATP-sensitive inward rectifier potassium channel 8 Swiss-port # Q63664 Rat ATP-sensitive inward rectifier potassium channel 8 |
|---|---|
| Gene Symbol | KCNJ8 |
| Gene Full Name | potassium channel, inwardly rectifying subfamily J, member 8 |
| Background | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012] |
| Function | This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). [UniProt] |
| Cellular Localization | Membrane; Multi-pass membrane protein. [UniProt] |
| Calculated MW | 48 kDa |
