ARG24120
anti-KCNQ4 antibody [N43/6]
anti-KCNQ4 antibody [N43/6] for ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Neuroscience antibody
Overview
| Product Description | Mouse Monoclonal antibody [N43/6] recognizes KCNQ4 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-Fr, IHC-P, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | N43/6 |
| Isotype | IgG1 |
| Target Name | KCNQ4 |
| Antigen Species | Human |
| Immunogen | Fusion protein of human KCNQ4 (a.a 2-77 ) |
| Conjugation | Un-conjugated |
| Alternate Names | DFNA2; Voltage-gated potassium channel subunit Kv7.4; KQT-like 4; DFNA2A; Potassium voltage-gated channel subfamily KQT member 4; KV7.4; Potassium channel subunit alpha KvLQT4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P56696 Human Potassium voltage-gated channel subfamily KQT member 4 Swiss-port # Q9JK97 Mouse Potassium voltage-gated channel subfamily KQT member 4 |
|---|---|
| Gene Symbol | KCNQ4 |
| Gene Full Name | Potassium Voltage-Gated Channel Subfamily Q Member 4 |
| Background | The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Research Area | Neuroscience antibody |
| Calculated MW | 77 kDa |
