ARG22225
anti-KCNT1 antibody [S3-26]
anti-KCNT1 antibody [S3-26] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [S3-26] recognizes KCNT1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Specificity | Detects ~140kDa. Weak human detection. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S3-26 |
| Isotype | IgG1 |
| Target Name | KCNT1 |
| Antigen Species | Rat |
| Immunogen | Fusion protein around aa. 1168-1237 of Rat KCNT1 |
| Conjugation | Un-conjugated |
| Alternate Names | EIEE14; SLACK; Potassium channel subfamily T member 1; Slo2.2; KCa4.1; ENFL5; bA100C15.2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Kcnt1 |
| Gene Full Name | potassium channel, sodium-activated subfamily T, member 1 |
| Background | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
| Function | Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). [UniProt] |
| Cellular Localization | Cell membrane |
| Calculated MW | 138 kDa |
| PTM | Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity (By similarity). |
