ARG53982
anti-KDM5C / Jarid 1C / SMCX antibody
anti-KDM5C / Jarid 1C / SMCX antibody for Western blot,ICC/IF and Human
Gene Regulation antibody
Overview
Product Description | Mouse Monoclonal antibody recognizes KDM5C / Jarid 1C / SMCX |
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Tested Reactivity | Hu |
Tested Application | ICC/IF, WB |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2a |
Target Name | KDM5C / Jarid 1C / SMCX |
Antigen Species | Human |
Immunogen | Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli |
Conjugation | Un-conjugated |
Alternate Names | XE169; SMCX; DXS1272E; JARID1C; Jumonji/ARID domain-containing protein 1C; Protein Xe169; Histone demethylase JARID1C; EC 1.14.11.-; MRX13; MRXJ; Lysine-specific demethylase 5C; MRXSJ; Protein SmcX; MRXSCJ |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
Observed Size | 220 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified |
Buffer | 0.1M Tris-Glycine (pH 7.4), 150 mM NaCl, 0.2% Sodium azide and 50% Glycerol |
Preservative | 0.2% Sodium azide |
Stabilizer | 50% Glycerol |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | KDM5C |
Gene Full Name | lysine (K)-specific demethylase 5C |
Background | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. |
Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). [UniProt] |
Cellular Localization | Nucleus |
Research Area | Gene Regulation antibody |
Calculated MW | 176 kDa |