ARG42371
anti-KIF5B / Kinesin Heavy Chain antibody
anti-KIF5B / Kinesin Heavy Chain antibody for ICC/IF,Western blot and Human,Mouse,Pig
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KIF5B / Kinesin Heavy Chain |
|---|---|
| Tested Reactivity | Hu, Ms, Pig |
| Tested Application | ICC/IF, WB |
| Specificity | The polyclonal antibody detects total level of endogenous kinesin protein (intracellular antigen). |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KIF5B / Kinesin Heavy Chain |
| Antigen Species | Human |
| Immunogen | Stalk domain of Human Kinesin (aa. 331-906). |
| Conjugation | Un-conjugated |
| Alternate Names | HEL-S-61; Kinesin-1 heavy chain; Conventional kinesin heavy chain; KINH; KNS1; Ubiquitous kinesin heavy chain; UKHC; KNS |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KIF5B |
| Gene Full Name | kinesin family member 5B |
| Function | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). [UniProt] |
| Cellular Localization | Cytoplasm, cytoskeleton. Note=Uniformly distributed between soma and neurites in hippocampal neurons. [UniProt] |
| Calculated MW | 110 kDa |
