ARG59681

anti-KIN / Kin17 antibody

anti-KIN / Kin17 antibody for Western blot and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes KIN / Kin17
Tested Reactivity Hu, Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name KIN / Kin17
Antigen Species Human
Immunogen Recombinant protein corresponding to K3-K202 of Human KIN.
Conjugation Un-conjugated
Alternate Names DNA/RNA-binding protein KIN17; KIN, antigenic determinant of recA protein homolog; Rts2; KIN17; Binding to curved DNA; BTCD

Application Instructions

Application Suggestion
Tested Application Dilution
WB0.1 - 0.5 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA.
Preservative 0.05% Sodium azide
Stabilizer 5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 16588 Mouse KIN

GeneID: 22944 Human KIN

Swiss-port # O60870 Human DNA/RNA-binding protein KIN17

Swiss-port # Q8K339 Mouse DNA/RNA-binding protein KIN17

Gene Symbol KIN
Gene Full Name Kin17 DNA and RNA binding protein
Background The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Function Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. [UniProt]
Cellular Localization Nucleus. Cytoplasm. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. [UniProt]
Calculated MW 45 kDa