ARG42417
anti-KIR2DL1 + KIR2DS5 + KIR2DS1 + KIRDS3 antibody [HP-MA4] (PE)
anti-KIR2DL1 + KIR2DS5 + KIR2DS1 + KIRDS3 antibody [HP-MA4] (PE) for Flow cytometry and Human
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody [HP-MA4] recognizes KIR2DL1 + KIR2DS5 + KIR2DS1 + KIRDS3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Specificity | The mouse monoclonal antibody HP-MA4 recognizes an extracellular epitope of CD158 isoforms KIR2DL1 (CD158a), KIR2DS5 (CD158g), KIR2DS1 (CD158h), and KIRDS3. It does not recognize the isoforms CD158b1,d,f,i,j. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HP-MA4 |
| Isotype | IgG2b, kappa |
| Target Name | KIR2DL1 + KIR2DS5 + KIR2DS1 + KIRDS3 |
| Antigen Species | Human |
| Immunogen | Human NK cell line LB2. |
| Conjugation | PE |
| Alternate Names | p58.1 MHC class-I-specific NK receptor; NKAT1; Killer cell immunoglobulin-like receptor 2DL1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; CD158A; KIR-K64; CD158 antigen-like family member A; p58.1; NKAT; p58 NK receptor CL-42/47.11; MHC class I NK cell receptor; Natural killer-associated transcript 1; CD antigen CD158a; KIR221 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P43626 Human Killer cell immunoglobulin-like receptor 2DL1 |
|---|---|
| Gene Symbol | KIR2DL1 |
| Gene Full Name | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 |
| Background | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
| Function | Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. [UniProt] |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 39 kDa |
