ARG42417

anti-KIR2DL1 + KIR2DS5 + KIR2DS1 + KIRDS3 antibody [HP-MA4] (PE)

anti-KIR2DL1 + KIR2DS5 + KIR2DS1 + KIRDS3 antibody [HP-MA4] (PE) for Flow cytometry and Human

Overview

Product Description PE-conjugated Mouse Monoclonal antibody [HP-MA4] recognizes KIR2DL1 + KIR2DS5 + KIR2DS1 + KIRDS3
Tested Reactivity Hu
Tested Application FACS
Specificity The mouse monoclonal antibody HP-MA4 recognizes an extracellular epitope of CD158 isoforms KIR2DL1 (CD158a), KIR2DS5 (CD158g), KIR2DS1 (CD158h), and KIRDS3. It does not recognize the isoforms CD158b1,d,f,i,j.
Host Mouse
Clonality Monoclonal
Clone HP-MA4
Isotype IgG2b, kappa
Target Name KIR2DL1 + KIR2DS5 + KIR2DS1 + KIRDS3
Antigen Species Human
Immunogen Human NK cell line LB2.
Conjugation PE
Alternate Names p58.1 MHC class-I-specific NK receptor; NKAT1; Killer cell immunoglobulin-like receptor 2DL1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; CD158A; KIR-K64; CD158 antigen-like family member A; p58.1; NKAT; p58 NK receptor CL-42/47.11; MHC class I NK cell receptor; Natural killer-associated transcript 1; CD antigen CD158a; KIR221

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl / 100 µl of whole blood or 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified
Buffer PBS and 15 mM Sodium azide.
Preservative 15 mM Sodium azide
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 3802 Human KIR2DL1

Swiss-port # P43626 Human Killer cell immunoglobulin-like receptor 2DL1

Gene Symbol KIR2DL1
Gene Full Name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
Background Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Function Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. [UniProt]
Cellular Localization Cell membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 39 kDa