ARG56918

anti-KIR2DS4 antibody [5F2]

anti-KIR2DS4 antibody [5F2] for Western blot and Human

Overview

Product Description Mouse Monoclonal antibody [5F2] recognizes KIR2DS4
Tested Reactivity Hu
Tested Application WB
Host Mouse
Clonality Monoclonal
Clone 5F2
Isotype IgG2b, kappa
Target Name KIR2DS4
Antigen Species Human
Immunogen Recombinant fragment of Human KIR2DS4.
Conjugation Un-conjugated
Alternate Names Natural killer-associated transcript 8; KKA3; NKAT8; KIR1D; NKAT-8; MHC class I NK cell receptor; p58 NK receptor CL-39/CL-17; P58 natural killer cell receptor clones CL-39/CL-17; CD158I; KIR412; KIR2DS1; CD158 antigen-like family member I; Killer cell immunoglobulin-like receptor 2DS4; CD antigen CD158i

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein G.
Buffer PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 10% Glycerol
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 3809 Human KIR2DS4

Swiss-port # P43632 Human Killer cell immunoglobulin-like receptor 2DS4

Gene Symbol KIR2DS4
Gene Full Name killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
Background Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Function Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. [UniProt]
Calculated MW 34 kDa