ARG54752
anti-KMT2D / MLL2 antibody
anti-KMT2D / MLL2 antibody for Western blot and Human
Gene Regulation antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KMT2D / MLL2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | KMT2D / MLL2 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 4980-5009 (C-terminus) of Human MLL2 (NP_003473.3). |
| Conjugation | Un-conjugated |
| Alternate Names | KABUK1; Lysine N-methyltransferase 2D; TNRC21; AAD10; MLL2; KMS; CAGL114; MLL4; Myeloid/lymphoid or mixed-lineage leukemia protein 2; EC 2.1.1.43; Histone-lysine N-methyltransferase 2D; ALR; ALL1-related protein |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O14686 Human Histone-lysine N-methyltransferase 2D |
|---|---|
| Gene Symbol | KMT2D |
| Gene Full Name | lysine (K)-specific methyltransferase 2D |
| Background | The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010] |
| Function | Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. [UniProt] |
| Cellular Localization | Nucleus. |
| Research Area | Gene Regulation antibody |
| Calculated MW | 593 kDa |
