ARG64368

anti-KMT3A / SETD2 antibody

anti-KMT3A / SETD2 antibody for Flow cytometry and Human

Gene Regulation antibody

Overview

Product Description

Goat Polyclonal antibody recognizes KMT3A / SETD2

Tested Reactivity Hu
Predict Reactivity Ms, Dog, Pig
Tested Application FACS
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name KMT3A / SETD2
Antigen Species Human
Immunogen C-ERDPDKQTQNKE
Conjugation Un-conjugated
Alternate Names HIF-1; SET domain-containing protein 2; SET2; Huntingtin-interacting protein B; Huntingtin yeast partner B; KMT3A; Huntingtin-interacting protein 1; hSET2; EC 2.1.1.43; HBP231; Lysine N-methyltransferase 3A; HIP-1; p231HBP; HSPC069; Histone-lysine N-methyltransferase SETD2; HYPB

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 29072 Human SETD2

Swiss-port # Q9BYW2 Human Histone-lysine N-methyltransferase SETD2

Background Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
Research Area Gene Regulation antibody
Calculated MW 288 kDa
PTM May be automethylated.