ARG44325
anti-Kindlin1 antibody
anti-Kindlin1 antibody for Western blot and Human,Mouse,Rat,Bovine,Dog,Primates,Xenopus
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Kindlin1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Bov, Dog, NHuPrm, Xenopus |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Kindlin1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide |
| Conjugation | Un-conjugated |
| Alternate Names | FERMT1; FERM Domain Containing Kindlin 1; KIND1; URP1; UNC112A; Fermitin Family Homolog 1; Unc-112-Related Protein 1; Fermitin Family Member 1; Kindlin Syndrome Protein; Kindlin-1; Kindlerin; FLJ20116; C20orf42; Fermitin Family Homolog 1 (Drosophila); Chromosome 20 Open Reading Frame 42; UNC112 Related Protein 1; Kinderlin; Kindlin 1; C20ORF42; DTGCU2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified |
| Buffer | PBS with 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | FERMT1 |
| Gene Full Name | FERM Domain Containing Kindlin 1 |
| Background | This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. |
| Function | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. |
| Cellular Localization | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane |
| Calculated MW | 77 kDa |
| PTM | Phosphoprotein |
