ARG24151
anti-Kir2.1 / KCNJ2 antibody [S112]
anti-Kir2.1 / KCNJ2 antibody [S112] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat,Monkey
Overview
| Product Description | Mouse Monoclonal antibody [S112] recognizes Kir2.1 / KCNJ2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Mk |
| Tested Application | ICC/IF, IHC-P, WB |
| Specificity | ~45kDa. No cross-reactivity against Kir2.2 or Kir2.3. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S112 |
| Isotype | IgG1 |
| Target Name | Kir2.1 / KCNJ2 |
| Antigen Species | Mouse |
| Immunogen | Fusion protein amino acids 41-64 and 189-428 of mouse Kir2.1 |
| Conjugation | Un-conjugated |
| Alternate Names | KCNJ2 ; Potassium Inwardly Rectifying Channel Subfamily J Member 2; IRK1; LQT7 Cardiac Inward Rectifier Potassium Channel; Inward Rectifier Potassium Channel 2; KIR2.1; IRK-1; HIRK1; Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KCNJ2 |
| Gene Full Name | Potassium Inwardly Rectifying Channel Subfamily J Member 2 |
| Background | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. |
| Function | Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. |
| Cellular Localization | Membrane |
| PTM | Disulfide bond, Lipoprotein, Myristate, S-nitrosylation |
Images (3) Click the Picture to Zoom In
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ARG24151 anti-Kir2.1 / KCNJ2 antibody [S112] IHC-P image
Immunohistochemistry: Mouse backskin stained with ARG24151 anti-Kir2.1 / KCNJ2 antibody [S112] at 1:100 dilution.
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ARG24151 anti-Kir2.1 / KCNJ2 antibody [S112] ICC/IF image
Immunofluorescence: SH-SY5Y stained with ARG24151 anti-Kir2.1 / KCNJ2 antibody [S112] at 1:50 dilution.
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ARG24151 anti-Kir2.1 / KCNJ2 antibody [S112] WB image
Western blot: COS stained with ARG24151 anti-Kir2.1 / KCNJ2 antibody [S112] at 1:1000 dilution.
