ARG56530

anti-LDL Receptor antibody

anti-LDL Receptor antibody for ICC/IF,Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes LDL Receptor
Tested Reactivity Hu, Ms, Rat
Tested Application ICC/IF, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name LDL Receptor
Antigen Species Mouse
Immunogen Synthetic peptide around the C-terminus of Mouse LDL receptor.
Conjugation Un-conjugated
Alternate Names FH; LDLCQ2; Low-density lipoprotein receptor; LDL receptor; FHC

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:100
WB1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer TBS (pH 7.4), 0.02% Sodium azide, 50% Glycerol and 0.1% BSA.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol and 0.1% BSA
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 16835 Mouse LDLR

GeneID: 300438 Rat LDLR

GeneID: 3949 Human LDLR

Gene Symbol Ldlr
Gene Full Name low density lipoprotein receptor
Background The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Function Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. [UniProt]
Highlight Related products:
LDL Receptor antibodies; LDL Receptor ELISA Kits; Anti-Rabbit IgG secondary antibodies;
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Calculated MW 95 kDa
PTM N- and O-glycosylated.
Ubiquitinated by MYLIP leading to degradation.