ARG42989

anti-LGR6 antibody

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Ordering Information

Package

Price (USD)

100 μl

399.00

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Overview

Product Description	Rabbit Polyclonal antibody recognizes LGR6
Tested Reactivity	Hu, Ms, Rat
Tested Application	FACS, ICC/IF, IHC-P, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	LGR6
Antigen Species	Human
Immunogen	Synthetic peptide derived from Human LGR6.
Conjugation	Un-conjugated
Alternate Names	Leucine-rich repeat-containing G-protein coupled receptor 6; GPCR; VTS20631

Application Instructions

Application Suggestion

Application Note

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Positive Control

HUVEC

Observed Size

~ 110 kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 329252 Mouse LGR6 GeneID: 59352 Human LGR6 Swiss-port # Q3UVD5 Mouse Leucine-rich repeat-containing G-protein coupled receptor 6 Swiss-port # Q9HBX8 Human Leucine-rich repeat-containing G-protein coupled receptor 6
Gene Symbol	LGR6
Gene Full Name	leucine-rich repeat containing G protein-coupled receptor 6
Background	This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Function	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. [UniProt]
Cellular Localization	Cell membrane; Multi-pass membrane protein. [UniProt]
Calculated MW	104 kDa