ARG66601

anti-LYVE1 antibody

anti-LYVE1 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,IHC-Frozen sections,Western blot and Human

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Overview

Product Description Rabbit Polyclonal antibody recognizes LYVE1
Tested Reactivity Hu
Tested Application FACS, IHC-Fr, IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name LYVE1
Antigen Species Human
Immunogen Recombinant Human LYVE1.
Conjugation Un-conjugated
Alternate Names Lymphatic vessel endothelial hyaluronic acid receptor 1; Hyaluronic acid receptor; LYVE-1; XLKD1; HAR; Extracellular link domain-containing protein 1; CRSBP-1; Cell surface retention sequence-binding protein 1

Application Instructions

Application Suggestion
Tested Application Dilution
FACSAssay-dependent
IHC-Fr1:30 - 1:200
IHC-P1:10-1:300
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer PBS
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 10894 Human LYVE1

Swiss-port # Q9Y5Y7 Human Lymphatic vessel endothelial hyaluronic acid receptor 1

Gene Symbol LYVE1
Gene Full Name lymphatic vessel endothelial hyaluronan receptor 1
Background This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
Function Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. [UniProt]
Calculated MW 35 kDa
PTM O-glycosylated. [UniProt]

Specific References

BRAF V600E mutant colorectal cancer cells mediate local immunosuppressive microenvironment through exosomal long noncoding RNAs

IHC-P / Human

Jie Zhi et al.
World J Gastrointest Oncol.,  (2022)

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