ARG10736
anti-Laminin 111 antibody
anti-Laminin 111 antibody for ICC/IF,IHC-Frozen sections,Western blot and Mouse,Rat
Publication2
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Laminin 111 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | ICC/IF, IHC-Fr, WB |
| Specificity | ARG10736 Laminin-111 antibody recognizes 3 laminin isotypes: α1 (440kDa), β1 (220kD) and γ1 (220kDa). |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Laminin 111 |
| Antigen Species | Mouse |
| Immunogen | Laminin isolated from Mouse EHS cells. |
| Conjugation | Un-conjugated |
| Alternate Names | LAMA; PTBHS; S-LAM-alpha; Laminin subunit alpha-1; laminin, beta 1; laminin, gamma 1 |
Application Instructions
| Application Suggestion |
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| Application Note | Note: Based on the reference PMID: 35453580 This antibody may also suitable for IHC-P application in human samples. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification. |
| Buffer | PBS and 50% Glycerol. |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Lama1 |
| Gene Full Name | laminin, alpha 1; laminin, beta 1; laminin, gamma 1 |
| Background | This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014] |
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. [UniProt] |
| Cellular Localization | Secreted › extracellular space › extracellular matrix › basement membrane Note: Major component. |
| Calculated MW | 337 kDa |
| PTM | Tyrosine phosphorylated by PKDCC/VLK. |
Specific References
Alginate-Laminin Hydrogel Supports Long-Term Neuronal Activity in 3D Human Induced Pluripotent Stem Cell-Derived Neuronal Networks
ICC/IF / Human
Alcohol-Induced Alterations in the Vascular Basement Membrane in the Substantia Nigra of the Adult Human Brain
IHC-P / Human
