ARG22704
anti-Laminin antibody
anti-Laminin antibody for ELISA,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Bird,Chicken,Dog,Duck,Pig,Rabbit
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Laminin This antibody recognizes both A (400kD) and B (220kD) chains of laminin. |
|---|---|
| Tested Reactivity | Hu, Ms, Bird, Chk, Dog, Duck, Pig, Rb |
| Tested Application | ELISA, ICC/IF, IHC-Fr, IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Laminin |
| Antigen Species | Mouse |
| Immunogen | Purified laminin from Engelbreth-Holm-Swarm (EHS). |
| Conjugation | Un-conjugated |
| Alternate Names | LAMA1: S-LAM-alpha; LAMA; Laminin-1 subunit alpha; PTBHS; Laminin-3 subunit alpha; S-LAM alpha; S-laminin subunit alpha; Laminin A chain; Laminin subunit alpha-1 LAMA2: Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain; Laminin M chain; LAMM; Laminin subunit alpha-2 LAMB1: Laminin-1 subunit beta; CLM; Laminin-8 subunit beta; Laminin-10 subunit beta; Laminin B1 chain; Laminin-12 subunit beta; LIS5; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin subunit beta-1 LAMB2: Laminin-3 subunit beta; S-laminin subunit beta; Laminin B1s chain; S-LAM beta; Laminin-4 subunit beta; LAMS; NPHS5; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-9 subunit beta; Laminin-11 subunit beta; Laminin-7 subunit beta; Laminin subunit beta-2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | Serum and 0.09% Sodium azide. |
| Preservative | 0.09% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | LAMA1; LAMA2; LAMB1; LAMB2 |
|---|---|
| Gene Full Name | laminin, alpha 1; laminin, alpha 2; laminin, beta 1; laminin, beta 2 (laminin S) |
| Background | LAMA1: This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014] |
| Function | LAMA1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. [UniProt] |
| Cellular Localization | LAMA1, LAMA2 and LAMB1: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. [UniProt] LAMB2: Secreted, extracellular space, extracellular matrix, basement membrane. Note=S-laminin is concentrated in the synaptic cleft of the neuromuscular junction. [UniProt] |
| PTM | LAMA1: Tyrosine phosphorylated by PKDCC/VLK. |
