ARG44359
anti-MAN2B1 antibody
anti-MAN2B1 antibody for Western blot and Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MAN2B1 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MAN2B1 |
| Antigen Species | Human |
| Immunogen | Human MAN2B1 recombinant fusion protein (a.a. sequence: 640-850). |
| Conjugation | Un-conjugated |
| Alternate Names | MAN2B1; Mannosidase Alpha Class 2B Member 1; LAMAN; Lysosomal Alpha-Mannosidase; MANB; Lysosomal Acid Alpha-Mannosidase; Mannosidase Alpha-B; EC 3.2.1.24; Mannosidase, Alpha, Class 2B, Member 1; Mannosidase, Alpha B, Lysosomal; EC 3.2.1; Laman |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS, 0.02% sodium azide and 50% Glycerol. |
| Preservative | 0.02% sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MAN2B1 |
| Gene Full Name | Mannosidase Alpha Class 2B Member 1 |
| Background | This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Function | Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages. |
| Cellular Localization | Lysosome |
| Calculated MW | 114 kDa |
| PTM | Disulfide bond, Glycoprotein, Zymogen |
